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Microbiota is an organ with its own functions that can modulate the expression of genes involved in the defense of mucosal barrier, angiogenesis and postnatal intestinal maturation. Changes in the composition of gut microbiota -dysbiosis- may be associated with nosocomial infections, necrotizing enterocolitis in premature infants, inflammatory bowel disease IBDobesity, rheumatologic autoimmune diseases and allergies. Dysbiosis increases intestinal permeability and the microbial translocation through the mucosa, thus resulting inflammation and metabolic endotoxemia. Therefore, are generated many proinflammatory cytokines and oxygen free radicals, all of which are considered triggers for the development of immuno-inflammatory systemic disease.

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